Wennersberg Marianne Hauge, Smedman Annika, Turpeinen Anu M, Retterstøl Kjetil, Tengblad Siv, Lipre Endla, Aro Antti, Mutanen Pertti, Seljeflot Ingebjørg, Basu Samar, Pedersen Jan I, Mutanen Marja, Vessby Bengt
Department of Nutrition, University of Oslo, Oslo, Norway.
Am J Clin Nutr. 2009 Oct;90(4):960-8. doi: 10.3945/ajcn.2009.27664. Epub 2009 Aug 26.
Some epidemiologic studies have suggested inverse relations between intake of dairy products and components of the metabolic syndrome.
The objective was to investigate the effects of an increased intake of dairy products in persons with a habitually low intake on body composition and factors related to the metabolic syndrome.
Middle-aged overweight subjects (n = 121) with traits of the metabolic syndrome were recruited in Finland, Norway, and Sweden and randomly assigned into milk or control groups. The milk group was instructed to consume 3-5 portions of dairy products daily. The control group maintained their habitual diet. Clinical investigations were conducted on admission and after 6 mo.
There were no significant differences between changes in body weight or body composition, blood pressure, markers of inflammation, endothelial function, adiponectin, or oxidative stress in the milk and the control groups. There was a modest unfavorable increase in serum cholesterol concentrations in the milk group (P = 0.043). Among participants with a low calcium intake at baseline (<700 mg/d), there was a significant treatment effect for waist circumference (P = 0.003) and sagittal abdominal diameter (P = 0.034). When the sexes were analyzed separately, leptin increased (P = 0.045) and vascular cell adhesion molecule-1 decreased (P = 0.001) in women in the milk group.
This study gives no clear support to the hypothesis that a moderately increased intake of dairy products beneficially affects aspects of the metabolic syndrome. The apparently positive effects on waist circumference and sagittal abdominal diameter in subjects with a low calcium intake suggest a possible threshold in relation to effects on body composition.
一些流行病学研究表明，乳制品摄入量与代谢综合征各组分之间存在负相关关系。
研究习惯性低乳制品摄入量人群增加乳制品摄入量对身体成分及与代谢综合征相关因素的影响。
在芬兰、挪威和瑞典招募了121名具有代谢综合征特征的中年超重受试者，并将其随机分为牛奶组或对照组。牛奶组受试者被要求每天食用3 - 5份乳制品。对照组维持其习惯饮食。在入组时和6个月后进行临床检查。
牛奶组和对照组在体重、身体成分、血压、炎症标志物、内皮功能、脂联素或氧化应激方面的变化无显著差异。牛奶组血清胆固醇浓度有适度的不利升高（P = 0.043）。在基线钙摄入量低（<700 mg/d）的参与者中，腰围（P = 0.003）和腹矢状径（P = 0.034）有显著的治疗效果。当分别分析性别时，牛奶组女性的瘦素升高（P = 0.045），血管细胞黏附分子-1降低（P = 0.001）。
本研究没有明确支持适度增加乳制品摄入量对代谢综合征各方面有有益影响这一假设。对钙摄入量低的受试者腰围和腹矢状径的明显积极影响表明，在对身体成分的影响方面可能存在一个阈值。
