Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Nutrients. 2021 Feb 4;13(2):506. doi: 10.3390/nu13020506.
Some studies suggest that dairy foods may be linked with less chronic inflammation. However, few studies have investigated the separate effects of different types of dairy on inflammation. Therefore, the current study aims to examine the separate prospective impacts of milk, yogurt and cheese on biomarkers of chronic inflammation in 1753 community-dwelling participants of the Framingham Offspring Study (FOS). Mean intakes of dairy foods were derived from two sets of three-day diet records. Six inflammatory biomarkers were assessed approximately seven years later at exam 7. Results showed that those who consumed yogurt (vs. those who did not) had statistically significantly lower levels of interleukin-6 (IL-6) (mean log-transformed levels of 1.31 and 1.26 in consumers/non-consumers, respectively, = 0.02) and fibrin (mean log-transformed levels of 5.91 and 5.89 in consumers/non-consumers, respectively, = 0.03). The inverse association between IL-6 and yogurt consumption was similar in participants who were of normal weight and those who were overweight. For fibrin, the effects were stronger in overweight individuals. No statistically significant associations were observed between any of these inflammation biomarkers and milk or cheese intakes. Overall, our study compared the separate impacts of three types of dairy foods on chronic inflammation and found that only yogurt intake was linked with lower levels of chronic inflammation.
一些研究表明，乳制品可能与较少的慢性炎症有关。然而，很少有研究调查不同类型的乳制品对炎症的单独影响。因此，本研究旨在探讨 1753 名弗雷明汉后代研究（Framingham Offspring Study，FOS）社区居民中牛奶、酸奶和奶酪对慢性炎症生物标志物的单独前瞻性影响。乳制品的平均摄入量来自两组为期三天的饮食记录。大约七年后，在第七次检查时评估了六种炎症生物标志物。结果表明，与不食用酸奶的人相比，食用酸奶的人（vs. 那些不食用酸奶的人）白细胞介素-6（IL-6）水平显著降低（分别为消费者/非消费者的 1.31 和 1.26， = 0.02）和纤维蛋白（分别为消费者/非消费者的 5.91 和 5.89， = 0.03）。在体重正常和超重的参与者中，IL-6 和酸奶消费之间的负相关关系相似。对于纤维蛋白，超重个体的影响更强。这些炎症生物标志物与牛奶或奶酪摄入量之间没有观察到统计学上显著的关联。总体而言，我们的研究比较了三种乳制品对慢性炎症的单独影响，发现只有酸奶摄入与较低水平的慢性炎症有关。
