Lee Y J, Seo J A, Yoon T, Seo I, Lee J H, Im D, Lee J H, Bahn K-N, Ham H S, Jeong S A, Kang T S, Ahn J H, Kim D H, Nam G E, Kim N H
Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, Korea.
Department of Endocrinology, Diabetes and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, Korea.
J Hum Nutr Diet. 2016 Aug;29(4):477-86. doi: 10.1111/jhn.12349. Epub 2016 Mar 6.
Previous studies of the health effects of low-fat milk or dairy consumption on the metabolic syndrome have yielded inconsistent results. The present study aimed to investigate the effects of low-fat milk consumption on traits associated with the metabolic syndrome, as well as inflammatory and atherogenic biomarkers, in Korean adults with the metabolic syndrome.
Overweight Koreans with the metabolic syndrome (n = 58) were recruited and randomly assigned to either the low-fat milk or control group. The low-fat milk group was instructed to consume two packs of low-fat milk per day (200 mL twice daily) for 6 weeks, and the control group was instructed to maintain their habitual diet. Clinical investigations were conducted during the screening visit, on study day 0, and after 6 weeks.
No significant differences in changes in body mass index, blood pressure, lipid profile and adiponectin levels, as well as levels of inflammatory markers, oxidative stress markers and atherogenic markers, were found between the low-fat milk and control groups. However, compared to the controls, significant favourable decreases in serum soluble vascular adhesion molecule-1 and endothelin-1 levels were found in the 12 subjects with high blood pressure and in the 18 subjects with hypertriglyceridaemia in the low-fat milk group.
The present study did not demonstrate an overall beneficial effect of low-fat milk consumption in subjects with the metabolic syndrome. However, low-fat milk consumption may have a favourable effect on atherogenic markers in subjects with high blood pressure or hypertriglyceridaemia.
先前关于低脂牛奶或乳制品消费对代谢综合征健康影响的研究结果并不一致。本研究旨在调查低脂牛奶消费对患有代谢综合征的韩国成年人中与代谢综合征相关的特征以及炎症和动脉粥样硬化生物标志物的影响。
招募了超重的患有代谢综合征的韩国人（n = 58），并将他们随机分配到低脂牛奶组或对照组。低脂牛奶组被指示每天饮用两包低脂牛奶（每次200 mL，每日两次），持续6周，对照组被指示保持其习惯饮食。在筛查访视时、研究第0天和6周后进行临床调查。
在低脂牛奶组和对照组之间，未发现体重指数、血压、血脂谱和脂联素水平以及炎症标志物、氧化应激标志物和动脉粥样硬化标志物水平的变化存在显著差异。然而，与对照组相比，低脂牛奶组中12名高血压患者和18名高甘油三酯血症患者的血清可溶性血管细胞粘附分子-1和内皮素-1水平出现了显著的有利下降。
本研究未证明低脂牛奶消费对患有代谢综合征的受试者具有总体有益效果。然而，低脂牛奶消费可能对高血压或高甘油三酯血症患者的动脉粥样硬化标志物有有利影响。
