Ngai S W, Chan Y M, Liu K L, Ho P C
Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Hum Reprod. 1997 Nov;12(11):2373-5. doi: 10.1093/humrep/12.11.2373.
Endometrial biopsy and hysteroscopy are important investigations in women presenting with abnormal vaginal bleeding. Endometrial biopsy is often performed as an outpatient procedure by endometrial aspiration. Difficulty in entering the internal cervical os may be encountered, especially in nulliparous women. The same problem may occur during hysteroscopy or dilatation and curettage. It is well known that use of a cervical priming agent is effective in reducing complications during cervical dilatation in pregnant women. However, its use in non-pregnant women is not well established. We compared oral misoprostol versus placebo for a cervical priming effect in non-pregnant women prior to hysteroscopy. The cumulative force required for cervical dilatation was significantly lower whereas the baseline cervical dilatation was significantly greater in the misoprostol group. We conclude that oral misoprostol is effective for pre-operative cervical dilatation in non-pregnant women.
子宫内膜活检和宫腔镜检查是出现异常阴道出血的女性的重要检查手段。子宫内膜活检通常作为门诊手术通过子宫内膜抽吸来进行。进入宫颈内口可能会遇到困难，尤其是在未生育过的女性中。在宫腔镜检查或刮宫时也可能出现同样的问题。众所周知，使用宫颈准备剂在减少孕妇宫颈扩张时的并发症方面是有效的。然而，其在非孕妇中的应用尚未得到充分证实。我们比较了口服米索前列醇与安慰剂在非孕妇宫腔镜检查前的宫颈准备效果。米索前列醇组宫颈扩张所需的累积力量明显更低，而基线宫颈扩张明显更大。我们得出结论，口服米索前列醇对非孕妇术前宫颈扩张有效。
