Cook J D, Carriaga M, Kahn S G, Schalch W, Skikne B S
Department of Medicine, Kansas University Medical Center, Kansas City 66103.
Lancet. 1990 May 12;335(8698):1136-9. doi: 10.1016/0140-6736(90)91135-w.
A gastric delivery system (GDS) for iron supplementation was evaluated. Radioisotopic studies in 9 volunteers demonstrated a three-fold higher absorption of GDS iron compared with ferrous sulphate elixir. A double-blind placebo controlled trial was done in 200 women to compare the gastrointestinal side-effects associated with 50 mg iron daily given either as GDS or conventional ferrous sulphate. The conventional preparation was associated with a significantly higher frequency of nausea and anorexia, whereas there were no significant differences in reported side-effects between subjects receiving GDS or placebo. A single GDS capsule daily provides the same amount of absorbed iron as conventional ferrous sulphate given three times daily, and does not produce gastrointestinal side-effects.
对一种用于补铁的胃内给药系统（GDS）进行了评估。对9名志愿者进行的放射性同位素研究表明，与硫酸亚铁酏剂相比，GDS铁的吸收高出三倍。在200名女性中进行了一项双盲安慰剂对照试验，以比较每日服用50毫克铁（以GDS或传统硫酸亚铁形式给药）所产生的胃肠道副作用。传统制剂出现恶心和厌食的频率明显更高，而接受GDS或安慰剂的受试者报告的副作用没有显著差异。每日服用一粒GDS胶囊所吸收的铁量与每日服用三次的传统硫酸亚铁相同，且不会产生胃肠道副作用。
