病毒作为治疗剂。I. 用病毒治疗非肥胖胰岛素依赖型糖尿病小鼠可预防胰岛素依赖型糖尿病，同时维持总体免疫能力。
Viruses as therapeutic agents. I. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes mellitus while maintaining general immune competence.
作者信息
Oldstone M B
机构信息
Department of Neuropharmacology, Research Institute of Stripps Clinic, La Jolla, California 92037.
出版信息
J Exp Med. 1990 Jun 1;171(6):2077-89. doi: 10.1084/jem.171.6.2077.
Abstract
A situation in which virus can be used as a therapeutic agent to prevent a lethal autoimmune disease is explored. Nonobese insulin-dependent diabetes (NOD) mice spontaneously develop insulin-dependent diabetes mellitus (IDDM), characterized by lymphocytic infiltration into the islets of Langerhans and beta cell destruction, resulting in hypoinsulinemia, hyperglycemia, ketoacidosis, and death. Infection of NOD mice with lymphocytic choriomeningitis virus (LCMV) aborts the autoimmune manifestations and resultant IDDM. The viruses' effect is on a subset of CD4+ lymphocytes. Ablating this autoimmune diabetes does not significantly alter immune responses to a variety of non-LCMV antigens that require CD4+ lymphocyte participation. The prevention of IDDM associated with viral therapy is maintained throughout the life spans of NOD mice.
摘要
本文探讨了病毒可作为治疗剂来预防致命性自身免疫性疾病的情况。非肥胖型胰岛素依赖型糖尿病（NOD）小鼠会自发发展为胰岛素依赖型糖尿病（IDDM），其特征是淋巴细胞浸润到胰岛中并导致β细胞破坏，进而引起低胰岛素血症、高血糖症、酮症酸中毒和死亡。用淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染NOD小鼠可中止自身免疫表现及由此导致的IDDM。该病毒的作用针对的是CD4 +淋巴细胞的一个亚群。消除这种自身免疫性糖尿病并不会显著改变对多种需要CD4 +淋巴细胞参与的非LCMV抗原的免疫反应。在NOD小鼠的整个生命周期中，病毒治疗对IDDM的预防作用一直存在。
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