Cheung Sin Wan, Chan Rufina, Cheng Roy Cs, Cho Pauline
The Centre of Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Clin Exp Optom. 2009 Nov;92(6):476-81. doi: 10.1111/j.1444-0938.2009.00419.x. Epub 2009 Aug 31.
Cycloplegia has been shown to have no effect on axial length measurement made with the IOLMaster in adults. The current study aimed at evaluating the effect of cycloplegia on axial length and anterior chamber depth (ACD) measurements made with the IOLMaster and an ultrasonic biometer in children.
Pre- and post-cycloplegic axial length and ACD were measured with the IOLMaster followed by the Sonomed A-5500 in 31 children aged from seven to 15 years by the same examiner. The 95% limits of agreement (LoA) were determined, if there were no significant correlations found between the mean differences and their means.
Seven subjects were excluded. Results from the remaining 24 subjects show that the effects of cycloplegia, instruments, and interaction between cycloplegia and instrument on axial length measurement were insignificant (repeated measure ANOVA F(1,23) < 2.19, p > 0.15). The 95% LoA in cycloplegia were better with the IOLMaster (-0.04 to 0.04 mm) than with the Sonomed A-5500 (-0.13 to 0.14 mm). The 95% LoA between the two instruments were similar with and without cycloplegia (pre-cycloplegia: -0.20 to 0.27 mm; post-cycloplegia: -0.17 to 0.22 mm). There was no significant interaction between cycloplegia and instrument in ACD measurement (repeated measure ANOVA F(1,23)= 0.85, p = 0.37), however, ACD was 0.05 to 0.06 mm shorter before cycloplegia (repeated measure ANOVA F(1,23)= 44.70, p < 0.001) and was 0.06 to 0.08 shorter measured with the IOLMaster (repeated measure ANOVA F(1,23)= 28.81, p < 0.001).
Effects of cycloplegia on axial length measurement in children made with IOLMaster and Sonomed A-5500 were insignificant. In contrast, ACD measurement was significantly affected by cycloplegia and different instruments.
已证实睫状肌麻痹对成人使用IOLMaster测量眼轴长度无影响。本研究旨在评估睫状肌麻痹对儿童使用IOLMaster和超声生物测量仪测量眼轴长度及前房深度（ACD）的影响。
由同一位检查者对31名7至15岁儿童，先用IOLMaster测量睫状肌麻痹前后的眼轴长度和ACD，随后再用Sonomed A - 5500进行测量。若平均差异与其均值之间未发现显著相关性，则确定95%一致性界限（LoA）。
排除7名受试者。其余24名受试者的结果显示，睫状肌麻痹、仪器以及睫状肌麻痹与仪器之间的相互作用对眼轴长度测量的影响不显著（重复测量方差分析F(1,23) < 2.19，p > 0.15）。使用IOLMaster时睫状肌麻痹状态下的95% LoA（-0.04至0.04毫米）优于Sonomed A - 5500（-0.13至0.14毫米）。两种仪器在有或无睫状肌麻痹情况下的95% LoA相似（睫状肌麻痹前：-0.20至0.27毫米；睫状肌麻痹后：-0.17至0.22毫米）。在ACD测量中，睫状肌麻痹与仪器之间没有显著的相互作用（重复测量方差分析F(1,23)= 0.85，p = 0.37），然而，睫状肌麻痹前ACD短0.05至0.06毫米（重复测量方差分析F(1,23)= 44.70，p < 0.001），使用IOLMaster测量时短0.06至０.08毫米（重复测量方差分析F(1,23)= 28.81，p < 0.001）。
睫状肌麻痹对儿童使用IOLMaster和Sonomed A - 5500测量眼轴长度的影响不显著。相比之下，ACD测量受睫状肌麻痹和不同仪器的显著影响。
