State University of New York College of Optometry, New York, NY, USA.
Retina Foundation of the Southwest, Dallas, TX, USA.
Transl Vis Sci Technol. 2024 May 1;13(5):25. doi: 10.1167/tvst.13.5.25.
PURPOSE: The purpose of this study was to investigate the development of optical biometric components in children with hyperopia, and apply a machine-learning model to predict axial length. METHODS: Children with hyperopia (+1 diopters [D] to +10 D) in 3 age groups: 3 to 5 years (n = 74), 6 to 8 years (n = 102), and 9 to 11 years (n = 36) were included. Axial length, anterior chamber depth, lens thickness, central corneal thickness, and corneal power were measured; all participants had cycloplegic refraction within 6 months. Spherical equivalent (SEQ) was calculated. A mixed-effects model was used to compare sex and age groups and adjust for interocular correlation. A classification and regression tree (CART) analysis was used to predict axial length and compared with the linear regression. RESULTS: Mean SEQ for all 3 age groups were similar but the 9 to 11 year old group had 0.49 D less hyperopia than the 3 to 5 year old group (P < 0.001). With the exception of corneal thickness, all other ocular components had a significant sex difference (P < 0.05). The 3 to 5 year group had significantly shorter axial length and anterior chamber depth and higher corneal power than older groups (P < 0.001). Using SEQ, age, and sex, axial length can be predicted with a CART model, resulting in lower mean absolute error of 0.60 than the linear regression model (0.76). CONCLUSIONS: Despite similar values of refractive errors, ocular biometric parameters changed with age in hyperopic children, whereby axial length growth is offset by reductions in corneal power. TRANSLATIONAL RELEVANCE: We provide references for optical components in children with hyperopia, and a machine-learning model for convenient axial length estimation based on SEQ, age, and sex.
目的:本研究旨在探讨远视儿童眼生物测量参数的发展,并应用机器学习模型预测眼轴长度。
方法:纳入远视(+1 屈光度[D]至+10 D)的 3 个年龄组儿童:3 至 5 岁(n=74)、6 至 8 岁(n=102)和 9 至 11 岁(n=36)。测量眼轴长度、前房深度、晶状体厚度、中央角膜厚度和角膜曲率;所有参与者在 6 个月内进行睫状肌麻痹验光。计算等效球镜(SEQ)。采用混合效应模型比较性别和年龄组,并调整眼间相关性。采用分类回归树(CART)分析预测眼轴长度,并与线性回归进行比较。
结果:3 个年龄组的平均 SEQ 相似,但 9 至 11 岁组的远视程度比 3 至 5 岁组低 0.49 D(P<0.001)。除了角膜厚度,所有其他眼部参数均存在显著的性别差异(P<0.05)。3 至 5 岁组的眼轴长度、前房深度较短,角膜曲率较高,与年龄较大的组相比差异有统计学意义(P<0.001)。使用 SEQ、年龄和性别,可以通过 CART 模型预测眼轴长度,其平均绝对误差为 0.60,低于线性回归模型(0.76)。
结论:尽管远视儿童的屈光不正值相似,但眼生物测量参数随年龄变化,眼轴长度的增长被角膜曲率的降低所抵消。
翻译贡献者:[姓名]
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