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本文引用的文献

1
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column.使用反相高效液相色谱柱通过液相色谱/电喷雾电离/串联质谱法定量测定溶血磷脂酸。
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 15;864(1-2):22-8. doi: 10.1016/j.jchromb.2008.01.031. Epub 2008 Feb 2.
2
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.用于定量血浆溶血磷脂的液相色谱质谱法：癌症诊断的潜在生物标志物
Methods Enzymol. 2007;433:1-25. doi: 10.1016/S0076-6879(07)33001-2.
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Determination of serum lysophosphatidic acid as a potential biomarker for ovarian cancer.血清溶血磷脂酸作为卵巢癌潜在生物标志物的测定
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):287-91. doi: 10.1016/j.jchromb.2007.08.008. Epub 2007 Aug 17.
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Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer.血浆溶血磷脂酰胆碱水平：结直肠癌的潜在生物标志物。
J Clin Oncol. 2007 Jul 1;25(19):2696-701. doi: 10.1200/JCO.2006.08.5571.
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[Lysophosphatidic acid in ovarian cancer patients].[卵巢癌患者中的溶血磷脂酸]
Ceska Gynekol. 2006 Jul;71(4):312-7.
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Quantification of lysophosphatidylcholines and phosphatidylcholines using liquid chromatography-tandem mass spectrometry in neonatal serum.采用液相色谱-串联质谱法对新生儿血清中的溶血磷脂酰胆碱和磷脂酰胆碱进行定量分析。
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 21;838(1):31-6. doi: 10.1016/j.jchromb.2006.03.006. Epub 2006 Apr 17.
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Application of 31P MRS to the analysis of phospholipid changes in plasma of patients with acute leukemia.31P磁共振波谱在急性白血病患者血浆磷脂变化分析中的应用。
Biochim Biophys Acta. 2005 Oct 15;1737(1):11-5. doi: 10.1016/j.bbalip.2005.08.019. Epub 2005 Sep 19.
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The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by 31P NMR and MALDI-TOF MS.人血浆中磷脂酰胆碱/溶血磷脂酰胆碱的比例是类风湿性关节炎严重程度的一个指标：通过31P核磁共振和基质辅助激光解吸电离飞行时间质谱进行的研究。
Clin Biochem. 2005 Oct;38(10):925-33. doi: 10.1016/j.clinbiochem.2005.06.006.
9
Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry.溃疡性结肠炎患者肠道黏液中的磷脂酰胆碱和溶血磷脂酰胆碱。通过纳米电喷雾串联质谱法的定量研究。
Scand J Gastroenterol. 2004 Aug;39(8):737-42. doi: 10.1080/00365520410006233.
10
Bone marrow transplantation in the course of hematological malignancies--follow-up study in blood serum by 31P MRS.血液系统恶性肿瘤病程中的骨髓移植——采用31P磁共振波谱法对血清进行的随访研究
Med Sci Monit. 2004 Aug;10(8):CR485-92. Epub 2004 Jul 23.

采用电喷雾串联质谱法（ESI-MS/MS）测定血浆样本中的内源性溶血磷脂酸，需要先对溶血磷脂酰胆碱进行预分离。

Measurement of endogenous lysophosphatidic acid by ESI-MS/MS in plasma samples requires pre-separation of lysophosphatidylcholine.

作者信息

Zhao Zhenwen, Xu Yan

机构信息

Department of Obstetrics and Gynecology, Indiana University Cancer Center, Indiana University School of Medicine, USA.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3739-42. doi: 10.1016/j.jchromb.2009.08.032. Epub 2009 Aug 27.

DOI:10.1016/j.jchromb.2009.08.032
PMID:19734112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2760648/
Abstract

The levels of lysophosphatidic acid (LPA) or lysophosphatidylcholine (LPC) in plasma have been shown to be markers for several human diseases, including cancers. Here we show that the presence of LPC or other lysophospholipids (LPLs) in lipids extracted from biological samples affects accurate measurement of endogenous LPA in biological samples. We report for the first time the artificial conversion of LPC and lysophosphatidylserine (LPS) to LPA at the ion source of electrospray ionization tandem mass spectrometry (ESI-MS/MS). To avoid the interference of LPC with the quantification of LPA, a method based on high-performance liquid chromatography (HPLC) separation of LPA from LPC has been developed.

摘要

血浆中溶血磷脂酸（LPA）或溶血磷脂酰胆碱（LPC）的水平已被证明是包括癌症在内的多种人类疾病的标志物。在这里，我们表明，从生物样品中提取的脂质中存在LPC或其他溶血磷脂（LPL）会影响生物样品中内源性LPA的准确测量。我们首次报告了在电喷雾电离串联质谱（ESI-MS/MS）的离子源处LPC和溶血磷脂酰丝氨酸（LPS）人工转化为LPA的情况。为避免LPC对LPA定量的干扰，已开发出一种基于高效液相色谱（HPLC）从LPC中分离LPA的方法。