肉桂对 2 型糖尿病患者糖化血红蛋白的影响：一项随机对照试验。
Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial.
机构信息
Nellis Family Medicine Residency, Mike O'Callaghan Federal Hospital, Las Vegas, NV 89191, USA.
出版信息
J Am Board Fam Med. 2009 Sep-Oct;22(5):507-12. doi: 10.3122/jabfm.2009.05.080093.
PURPOSE
Multiple trials in the past have shown conflicting results of whether cinnamon lowers glucose or hemoglobin A1C (HbA1C). The purpose of this study was to determine whether cinnamon lowers HbA1C in patients with type 2 diabetes. I performed a randomized, controlled trial to evaluate whether daily cinnamon plus usual care versus usual care alone lowers HbA1c.
METHODS
I randomized 109 type 2 diabetics (HbA1C >7.0) from 3 primary care clinics caring for pediatric, adult, and geriatric patients at a United States military base. Participants were randomly allocated to either usual care with management changes by their primary care physician or usual care with management changes plus cinnamon capsules, 1g daily for 90 days. HbA1c was drawn at baseline and 90 days and compared with intention-to-treat analysis. This study was approved by an institutional review board.
RESULTS
Cinnamon lowered HbA1C 0.83% (95% CI, 0.46-1.20) compared with usual care alone lowering HbA1C 0.37% (95% CI, 0.15-0.59).
CONCLUSIONS
Taking cinnamon could be useful for lowering serum HbA1C in type 2 diabetics with HbA1C >7.0 in addition to usual care.
目的
过去的多项试验表明，肉桂是否能降低血糖或糖化血红蛋白（HbA1C）的结果存在矛盾。本研究旨在确定肉桂是否能降低 2 型糖尿病患者的 HbA1C。我们进行了一项随机对照试验，以评估肉桂加常规护理与单纯常规护理相比是否能降低 HbA1c。
方法
我们从美国军事基地的 3 个初级保健诊所中随机招募了 109 名 2 型糖尿病患者（HbA1C>7.0）。参与者被随机分配到常规护理组或常规护理加肉桂胶囊组，每天 1 克，持续 90 天。在基线和 90 天时抽取 HbA1c，并进行意向治疗分析。本研究得到了机构审查委员会的批准。
结果
与单纯常规护理组相比，肉桂组 HbA1C 降低了 0.83%（95%CI，0.46-1.20），而常规护理组降低了 0.37%（95%CI，0.15-0.59）。
结论
除了常规护理外，肉桂可能对 HbA1C>7.0 的 2 型糖尿病患者降低血清 HbA1C 有用。
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