Miyagawa A, Chiba M, Hayashi H, Igarashi K
Division of Oral Dysfunction Science, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
J Dent Res. 2009 Aug;88(8):752-6. doi: 10.1177/0022034509341637.
During orthodontic tooth movement, the activation of the vascular system in the compressed periodontal ligament (PDL) is an indispensable process in tissue remodeling. We hypothesized that compressive force would induce angiogenesis of PDL through the production of vascular endothelial growth factor (VEGF). We examined the localization of VEGF in rat periodontal tissues during experimental tooth movement in vivo, and the effects of continuous compressive force on VEGF production and angiogenic activity in human PDL cells in vitro. PDL cells adjacent to hyalinized tissue and alveolar bone on the compressive side showed marked VEGF immunoreactivity. VEGF mRNA expression and production in PDL cells increased, and conditioned medium stimulated tube formation. These results indicate that continuous compressive force enhances VEGF production and angiogenic activity in PDL cells, which may contribute to periodontal remodeling, including angiogenesis, during orthodontic tooth movement.
在正畸牙齿移动过程中，受压牙周膜（PDL）中血管系统的激活是组织重塑中不可或缺的过程。我们假设压力会通过血管内皮生长因子（VEGF）的产生诱导PDL血管生成。我们研究了体内实验性牙齿移动过程中VEGF在大鼠牙周组织中的定位，以及持续压力对体外培养的人PDL细胞中VEGF产生和血管生成活性的影响。受压侧与透明样组织和牙槽骨相邻的PDL细胞显示出明显的VEGF免疫反应性。PDL细胞中VEGF mRNA表达和产生增加，条件培养基刺激管形成。这些结果表明，持续压力增强了PDL细胞中VEGF的产生和血管生成活性，这可能有助于正畸牙齿移动过程中的牙周重塑，包括血管生成。
