Akbar Yun Mukmin, Maskoen Ani Melani, Mardiati Endah, Wandawa Ganesha, Setiawan Arlette Suzy
Doctoral Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Department of Research Development, Indonesian Naval Dental Institute R.E. Martadinata, Jakarta, Indonesia.
Eur J Dent. 2023 Feb;17(1):16-23. doi: 10.1055/s-0042-1755625. Epub 2022 Oct 11.
Understanding the fundamental principles of tooth movement could reduce the duration of treatment and achieve a stable outcome, resulting in patient satisfaction. Hyperbaric oxygen therapy was a modality in which a patient inhaled 100% O while subjected to high atmospheric pressure. Hyperbaric oxygen therapy facilitated the supply of oxygen to the human body's organs and tissues and served a variety of applications, including patient care and wound treatment. This review article aimed to describe animal studies of the potential effects of hyperbaric oxygen therapy in orthodontic therapy. It was conducted using a systematic literature review method, including searching PubMed and Google Scholar for publications relevant to the research topics. The search was filtered to include only research on orthodontic treatment and hyperbaric oxygen therapy and was published in any year. Articles that did not specify biological components of orthodontic tooth movement (OTM) were excluded. The Preferred Reporting Items identified the papers for the Systematic Reviews and Meta-Analyses (PRISMA) strategy, which resulted in the selection of 11 publications. Hyperbaric oxygen therapy affected parameters of biomarkers representing the clinical, molecular, and cellular biology of bone formation and resorption in periodontal tissues in responding to orthodontic physical forces, including alkaline phosphatase, collagen synthesis, osteoblast, osteoclast, osteocyte, type I collagen, vascular endothelial growth factor, osteocalcin, fibroblast, matrix metalloproteinase-8, transforming growth factor-β, partial pressure of oxygen, partial pressure of carbon dioxide, trabecular bone density, and tooth mobility. Hyperbaric oxygen therapy induced an inflammatory response to follow OTM events during active orthodontic therapy. Hyperbaric oxygen therapy might play a role in the tissue healing process during passive treatment. Nonetheless, additional research should be conducted to establish the efficacy of hyperbaric oxygen therapy in orthodontics.
了解牙齿移动的基本原理可以缩短治疗时间并获得稳定的治疗效果，从而提高患者满意度。高压氧治疗是一种让患者在高气压环境下吸入100%氧气的治疗方式。高压氧治疗有助于向人体器官和组织供氧，并具有多种应用，包括患者护理和伤口治疗。这篇综述文章旨在描述关于高压氧治疗在正畸治疗中潜在作用的动物研究。该研究采用系统文献综述方法进行，包括在PubMed和谷歌学术上搜索与研究主题相关的出版物。搜索结果经过筛选，只纳入关于正畸治疗和高压氧治疗的研究，且不限发表年份。未明确提及正畸牙齿移动（OTM）生物学成分的文章被排除。采用系统评价和Meta分析的首选报告项目（PRISMA）策略筛选文献，最终选定11篇出版物。高压氧治疗会影响代表牙周组织对正畸物理力作出反应时骨形成和吸收的临床、分子和细胞生物学的生物标志物参数，包括碱性磷酸酶、胶原蛋白合成、成骨细胞、破骨细胞、骨细胞、I型胶原蛋白、血管内皮生长因子、骨钙素、成纤维细胞、基质金属蛋白酶-8、转化生长因子-β、氧分压、二氧化碳分压、骨小梁密度和牙齿移动度。在积极的正畸治疗过程中，高压氧治疗会引发炎症反应以伴随OTM事件。在被动治疗期间，高压氧治疗可能在组织愈合过程中发挥作用。尽管如此，仍需开展更多研究以确定高压氧治疗在正畸治疗中的疗效。
