关于幂先的注释。

A note on the power prior.

机构信息

Novartis Pharma AG, Biometrics, Basel, Switzerland.

出版信息

Stat Med. 2009 Dec 10;28(28):3562-6. doi: 10.1002/sim.3722.

PMID:19735071

Abstract

The power prior by Ibrahim and Chen (Statist. Sci. 2000; 15:46-60) is one of several methods to incorporate historical data in the analysis of a clinical trial. The power prior raises the likelihood of the historical data to the power parameter a(0) which quantifies the discounting of the historical data due to heterogeneity between trials. It is shown that the standard method of estimating the power parameter from the historical and current data is inappropriate, and we therefore suggest to use a modified power prior approach or to consider alternative methods instead.

摘要

Ibrahim 和 Chen（《统计科学》2000 年；15：46-60）提出的先验功效是将历史数据纳入临床试验分析的几种方法之一。先验功效将历史数据的可能性提升到功效参数 a(0)，该参数量化了由于试验之间的异质性导致对历史数据的折扣。结果表明，从历史和当前数据中估计功效参数的标准方法是不恰当的，因此我们建议使用修正的先验功效方法或考虑替代方法。