Tefre T, Børresen A L, Aamdal S, Brøgger A
Department of Genetics, Norwegian Radium Hospital, Oslo, Norway.
Br J Cancer. 1990 Jun;61(6):809-12. doi: 10.1038/bjc.1990.182.
We studied 83 lung cancer patients and 129 controls for the EcoRI polymorphism of the L-myc gene. No association was found between the L-myc RFLP and increased risk of metastasis, either to lymph nodes or metastasis to other organs. There was no difference in survival time between the three different genotypes. The S-allele of the L-myc RFLP has been correlated to increased metastasis in lung cancer. We found no tendency towards a higher frequency of this allele in the cohort of patients with positive family history compared to the patients with no known first degree relatives with cancer. A higher frequency of the S-allele in the adenocarcinomas compared to other histological groups was found, although this difference was not statistically significant. No difference in the gene frequency of the L-myc RFLP was found between the lung cancer patients and the normal controls. These results are in contrast with a previous report. Possible explanations for the discrepancies are discussed.
我们对83例肺癌患者和129例对照进行了L-myc基因EcoRI多态性研究。未发现L-myc限制性片段长度多态性（RFLP）与转移风险增加之间存在关联，无论是转移至淋巴结还是转移至其他器官。三种不同基因型之间的生存时间没有差异。L-myc RFLP的S等位基因与肺癌转移增加相关。我们发现，与无已知癌症一级亲属的患者相比，有阳性家族史的患者队列中该等位基因频率没有更高的趋势。与其他组织学类型相比，腺癌中S等位基因的频率更高，尽管这种差异无统计学意义。肺癌患者和正常对照之间未发现L-myc RFLP基因频率存在差异。这些结果与之前的一份报告相反。文中讨论了差异存在的可能原因。
