一种具有多个结构正常染色体拷贝的人肝癌细胞系。
A human hepatocellular carcinoma cell line with multiple copies of structurally normal chromosomes.
作者信息
Wuu K D, Wuu S W, Hu C P, Chang C M
机构信息
Institute of Genetics, National Yang Ming Medical College, Taipei, Taiwan, R.O.C.
出版信息
J Formos Med Assoc. 1990 Jan;89(1):1-5.
At Veterans General Hospital (VGH), a cell line, HA59T(HA59T/VGH), was established from a primary hepatocellular carcinoma of a 52-year-old Chinese male patient. G-banded metaphases were analyzed at passages 12 and 62. Of the 200 cells counted, 68% had 100-110 chromosomes/cell at passage 12, and 74% had 90-100 chromosomes/cell at passage 62. The presence of multiple copies of a structurally normal chromosome in a single cell was common for most of the chromosomes. Both X and Y sex chromosomes were normally present in the majority of the cells. This cell line is karyotypically different from those reported in other literature.
在荣民总医院（VGH），一株名为HA59T（HA59T/VGH）的细胞系是从一名52岁中国男性患者的原发性肝细胞癌中建立的。在第12代和第62代时对G带中期染色体进行了分析。在计数的200个细胞中，第12代时68%的细胞每条细胞含有100 - 110条染色体，第62代时74%的细胞每条细胞含有90 - 100条染色体。单个细胞中结构正常的染色体存在多个拷贝的情况在大多数染色体中都很常见。大多数细胞中X和Y性染色体均正常存在。该细胞系的核型与其他文献报道的不同。
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