PMNM Dental College and Hospital, Bagalkot, Karnataka, India.
Aust Dent J. 2009 Sep;54 Suppl 1:S102-9. doi: 10.1111/j.1834-7819.2009.01148.x.
The oral cavity is colonized by a large number and highly diversified communities of micro-organisms. Bacterial biofilm present on tooth or root surface is a major cause of gingivitis and periodontitis. Chemical antimicrobial agents are widely used in prophylactic and therapeutic regimens for dental plaque related diseases, which are among the most common human infections. As these agents are difficult to maintain at therapeutic concentrations in the oral cavity and can be rendered ineffective by resistance development in target organisms, there is a need for an alternative antimicrobial approach. A novel approach, photodynamic therapy (PDT), could be a solution to these problems. Lethal photosensitization of many bacteria, both Gram positive and Gram negative was found in many studies. The advantage of this new approach includes rapid bacterial elimination, minimal chance of resistance development and safety of adjacent host tissue and normal microflora. Thus, the available knowledge of photodynamic therapy should encourage a more clinically oriented application of this technique.
口腔内定植着大量且高度多样化的微生物群落。存在于牙齿或牙根表面的细菌生物膜是导致牙龈炎和牙周炎的主要原因。化学抗菌剂被广泛用于与牙菌斑相关疾病的预防和治疗方案中，这些疾病是最常见的人类感染之一。由于这些药物在口腔中难以维持治疗浓度，并且由于目标生物体内的耐药性发展而变得无效，因此需要一种替代的抗菌方法。一种新的方法，光动力疗法（PDT），可能是解决这些问题的方法。在许多研究中发现，许多革兰氏阳性和革兰氏阴性细菌都存在致命的光敏化作用。这种新方法的优点包括快速消除细菌、耐药性发展的机会极小以及对相邻宿主组织和正常微生物群的安全性。因此，现有的光动力疗法知识应该鼓励更临床导向的应用这种技术。
