Szymaniec J, Trzeciak H I, Machalska H, Turczyński B
Med Pr. 1977;28(3):189-92.
Male Wistar rats were treated intraperitoneally once per week for 12 weeks with following detergents: Olbrotol-18 (nonionic detergent), a product of etheric condensation of 18 moles of ethylene oxide to 1 mole of the mixture of olein alcohol and cetyl alkohol in ratio 1:1, in a dose of 10 mg/kg; SBO (anionic detergent), sodium 2-ethylhexylsulfosuccinate, in a dose of 10 mg/kg and Sterinol (cationic detergent), benzalkonium bromide, in a dose of 0.6 mg/kg. The control rats were injected with 0.9% saline solution. The content of total cholesterol, beta-lipoproteins and total lipids in serum were estimated. The increase of total cholesterol and the decrease of beta-lipoproteins content in serum of rats after all used detergents were observed as compared with the control. The increase of total lipid content only after long-term treatment with Olbrotol-18 was found. It is concluded that long term intraperitoneal treatment with detergents changes similarly the contents of total cholesterol and of beta-lipoproteins in blood serum of rats.
将雄性Wistar大鼠每周腹腔注射一次，持续12周，使用以下洗涤剂：Olbrotol-18（非离子洗涤剂），由18摩尔环氧乙烷与1摩尔油酸醇和十六醇按1:1比例混合的醚化缩合产物，剂量为10毫克/千克；SBO（阴离子洗涤剂），2-乙基己基磺基琥珀酸钠，剂量为10毫克/千克；以及Sterinol（阳离子洗涤剂），苯扎溴铵，剂量为0.6毫克/千克。对照大鼠注射0.9%生理盐水溶液。测定血清中总胆固醇、β-脂蛋白和总脂质的含量。与对照组相比，观察到所有使用的洗涤剂处理后大鼠血清中总胆固醇升高，β-脂蛋白含量降低。仅在长期用Olbrotol-18处理后发现总脂质含量增加。得出结论，长期腹腔注射洗涤剂会类似地改变大鼠血清中总胆固醇和β-脂蛋白的含量。
