Zigmond R E, Ben-Ari Y
Proc Natl Acad Sci U S A. 1977 Jul;74(7):3078-80. doi: 10.1073/pnas.74.7.3078.
The effect of synaptic stimulation on tyrosine hydroxylase [tyrosine 3-monooxygenase: L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity in the rat superior cervical ganglion was studied. The preganglionic cervical sympathetic trunk was stimulated unilaterally at 10 Hz for 30 min. Forty-eight hours later tyrosine hydroxylase activity was 33% higher on the stimulated than on the control side. The enzyme activity restimulated than on the control side. The enzyme activity remained elevated in the stimulated ganglia for 2 days. No change was observed in total ganglion protein. Comparable increases in tyrosine hydroxylase activity were observed in anesthetized and conscious animals.
研究了突触刺激对大鼠颈上神经节中酪氨酸羟化酶[酪氨酸3-单加氧酶：L-酪氨酸，四氢蝶呤：氧氧化还原酶（3-羟化），EC 1.14.16.2]活性的影响。节前颈交感干以10Hz单侧刺激30分钟。48小时后，受刺激侧的酪氨酸羟化酶活性比对照侧高33%。该酶活性在受刺激侧比对照侧再次刺激时更高。在受刺激的神经节中，酶活性持续升高2天。神经节总蛋白未观察到变化。在麻醉和清醒动物中均观察到酪氨酸羟化酶活性有类似增加。
