应激干细胞：将应激与心血管疾病中的造血联系起来。
Stressing out stem cells: linking stress and hematopoiesis in cardiovascular disease.
机构信息
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
出版信息
Nat Med. 2014 Jul;20(7):707-8. doi: 10.1038/nm.3631.
Abstract
Stress has long been thought to be a major contributing factor to cardiovascular disease, although little is known about the underlying cellular mechanisms. A new study illustrates that chronic stress promotes hematopoietic stem cell proliferation in bone marrow, leading to increased leukocyte production, circulation, and recruitment to the vasculature.
摘要
长期以来，压力一直被认为是导致心血管疾病的一个主要因素，尽管对于潜在的细胞机制知之甚少。一项新的研究表明，慢性压力会促进骨髓中的造血干细胞增殖，导致白细胞生成、循环和向血管系统的募集增加。
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Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16574-9. doi: 10.1073/pnas.1310655110. Epub 2013 Sep 23.
2
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Semin Immunopathol. 2013 Sep;35(5):553-62. doi: 10.1007/s00281-013-0387-3. Epub 2013 Jul 10.
3
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Atherosclerosis. 2012 Jul;223(1):69-77. doi: 10.1016/j.atherosclerosis.2012.01.021. Epub 2012 Jan 18.
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