借助新合成的补骨脂素衍生物对一种RNA动物病毒——水疱性口炎病毒进行光灭活。
The photoinactivation of an RNA animal virus, vesicular stomatitis virus, with the aid of newly synthesized psoralen derivatives.
作者信息
Hearst J E, Thiry L
出版信息
Nucleic Acids Res. 1977;4(5):1339-47. doi: 10.1093/nar/4.5.1339.
Abstract
The newly synthesized psoralen derivatives, 4' hydroxymethyl 4,5',8 trimethylpsoralen, 4' methoxymethyl 4,5',8 trimethylpsoralen, and 4' aminomethyl 4,5',8 trimethylpsoralen hydrochloride photoreact with the single-stranded RNA animal virus, Vesicular Stomatitis virus, VSV. This virus is inactivated 10(3) times more effectively by photoreaction with these compounds than when photoreacted with 4,5',8 trimethylpsoralen. Under these conditions the RNA virus remains more than 10(3) times less sensitive to inactivation by these new photoreagents than were two double-stranded DNA viruses, Herpes Simplex type 2 (HSV-2) and Vaccinia. Preliminary evidence for the generality of this result is discussed.
摘要
新合成的补骨脂素衍生物，4'-羟甲基-4,5',8-三甲基补骨脂素、4'-甲氧基甲基-4,5',8-三甲基补骨脂素和4'-氨甲基-4,5',8-三甲基补骨脂素盐酸盐可与单链RNA动物病毒水疱性口炎病毒（VSV）发生光反应。与这些化合物进行光反应时，该病毒的灭活效率比与4,5',8-三甲基补骨脂素进行光反应时高10³倍。在这些条件下，RNA病毒对这些新光试剂灭活的敏感性仍比对两种双链DNA病毒，即2型单纯疱疹病毒（HSV-2）和痘苗病毒低10³倍以上。本文讨论了这一结果普遍性的初步证据。
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The photoinactivation of an RNA animal virus, vesicular stomatitis virus, with the aid of newly synthesized psoralen derivatives.借助新合成的补骨脂素衍生物对一种RNA动物病毒——水疱性口炎病毒进行光灭活。
Nucleic Acids Res. 1977;4(5):1339-47. doi: 10.1093/nar/4.5.1339.
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