Jaeger Luc
Chemistry and Biochemistry Department, Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106-9510, USA.
Nucleic Acids Symp Ser (Oxf). 2009(53):83-4. doi: 10.1093/nass/nrp042.
Stable RNAs are modular and hierarchical three-dimensional (3D) architectures taking advantage of recurrent structural motifs to form extensive non-covalent tertiary interactions (1, 2). Using comparative sequence and structural analysis of known X-ray structures of RNAs, folding and assembly principles of RNA can presently be gathered to generate the syntax of a proto-language for rational design and prediction of RNA 3D shapes. RNA architectonics refers to the deciphering of this proto-language and to its use to build new functional RNA shapes with self-assembly properties (3-5). This approach can therefore contribute to the prediction and rational design of RNA tertiary structures for potential applications in nanotechnology, synthetic biology and medicine.
稳定RNA是模块化的分层三维（3D）结构，利用反复出现的结构基序形成广泛的非共价三级相互作用（1,2）。通过对已知RNA的X射线结构进行比较序列和结构分析，目前可以总结出RNA的折叠和组装原理，以生成一种原始语言的语法，用于合理设计和预测RNA的3D形状。RNA建筑学是指对这种原始语言的破译，以及利用它构建具有自组装特性的新功能RNA形状（3-5）。因此，这种方法有助于预测和合理设计RNA三级结构，以用于纳米技术、合成生物学和医学等潜在应用。
