阿洛他胺A，一种源自海洋蓝藻布氏鞘丝藻的新型神经药理学试剂。
Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.
作者信息
Soria-Mercado Irma E, Pereira Alban, Cao Zhengyu, Murray Thomas F, Gerwick William H
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92037, USA.
出版信息
Org Lett. 2009 Oct 15;11(20):4704-7. doi: 10.1021/ol901438b.
Abstract
Alotamide A (1), a structurally intriguing cyclic depsipeptide, was isolated from the marine mat-forming cyanobacterium Lyngbya bouillonii collected in Papua New Guinea. It features three contiguous peptidic residues and an unsaturated heptaketide with oxidations and methylations unlike those found in any other marine cyanobacterial metabolite. Pure alotamide A (1) displays an unusual calcium influx activation profile in murine cerebrocortical neurons with an EC50 of 4.18 microM.
摘要
阿洛他胺A（1）是一种结构引人入胜的环缩肽，从采集于巴布亚新几内亚的形成菌垫的海洋蓝细菌布氏鞘丝藻中分离得到。它具有三个相邻的肽残基和一个带有氧化和甲基化修饰的不饱和七酮酸，这些修饰与其他任何海洋蓝细菌代谢产物中的修饰不同。纯的阿洛他胺A（1）在小鼠大脑皮质神经元中显示出异常的钙内流激活曲线，其半数有效浓度（EC50）为4.18微摩尔。
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