林格布伊洛苷，一种从海洋蓝藻布氏林格藻中提取的新型糖苷大环内酯。
Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii.
作者信息
Tan Lik Tong, Márquez Brian L, Gerwick William H
机构信息
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
出版信息
J Nat Prod. 2002 Jun;65(6):925-8. doi: 10.1021/np010526c.
A glycosidic macrolide, lyngbouilloside (1), was characterized from the marine cyanobacterium Lyngbya bouillonii collected from Papua New Guinea. Its structure was elucidated by spectroscopic analysis and chemical derivatization. Relative stereochemistry was deduced from homonuclear and heteronuclear coupling constants as well as NOE information. Lyngbouilloside was modestly cytotoxic to neuroblastoma cells (IC(50) value of 17 microM).
从采集自巴布亚新几内亚的海洋蓝藻博伊森席藻（Lyngbya bouillonii）中鉴定出一种糖苷类大环内酯化合物——林格布伊洛苷（1）。通过光谱分析和化学衍生化确定了其结构。根据同核和异核偶合常数以及NOE信息推断出相对立体化学结构。林格布伊洛苷对神经母细胞瘤细胞具有一定的细胞毒性（IC50值为17微摩尔）。
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