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粪肠球菌中庆大霉素耐药基因的转移

Mobilization of the gentamicin resistance gene in Enterococcus faecalis.

作者信息

Hodel-Christian S L, Murray B E

机构信息

Program in Infectious Diseases and Clinical Microbiology, University of Texas Medical School, Houston 77030.

出版信息

Antimicrob Agents Chemother. 1990 Jun;34(6):1278-80. doi: 10.1128/AAC.34.6.1278.

DOI:10.1128/AAC.34.6.1278
PMID:1975489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171802/
Abstract

Enterococcus faecalis plasmid pBEM10 (a conjugative plasmid encoding beta-lactamase production and gentamicin resistance [Gmr]) was made transfer deficient by using Tn917. Relocation of the Gmr determinant into two sites on pCF10 was observed. Restriction analysis revealed insertion of a common 2.5-kilobase-pair HindIII and a 3.9-kilobase-pair HaeIII fragment encoding Gmr, suggesting that this determinant resides on a transposon similar to Tn4001.

摘要

粪肠球菌质粒pBEM10（一种编码β-内酰胺酶产生和庆大霉素抗性[Gmr]的接合性质粒）通过使用Tn917使其转移缺陷。观察到Gmr决定簇重新定位到pCF10上的两个位点。限制性分析显示插入了一个常见的2.5千碱基对的HindIII片段和一个3.9千碱基对的编码Gmr的HaeIII片段，这表明该决定簇位于一个类似于Tn4001的转座子上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60ef/171802/94a4aeb3f6db/aac00062-0379-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60ef/171802/94a4aeb3f6db/aac00062-0379-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60ef/171802/94a4aeb3f6db/aac00062-0379-a.jpg

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Antimicrob Agents Chemother. 1990 Nov;34(11):2106-13. doi: 10.1128/AAC.34.11.2106.
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Characterization of the gentamicin resistance transposon Tn5281 from Enterococcus faecalis and comparison to staphylococcal transposons Tn4001 and Tn4031.粪肠球菌庆大霉素抗性转座子Tn5281的特性分析及其与葡萄球菌转座子Tn4001和Tn4031的比较。
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Antimicrob Agents Chemother. 1992 Jan;36(1):230-2. doi: 10.1128/AAC.36.1.230.
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Identical genes confer high-level resistance to gentamicin upon Enterococcus faecalis, Enterococcus faecium, and Streptococcus agalactiae.相同的基因赋予粪肠球菌、屎肠球菌和无乳链球菌对庆大霉素的高水平抗性。
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Plasmid-mediated resistance to aminocyclitol antibiotics in group D streptococci.D群链球菌中质粒介导的对氨基环醇类抗生素的耐药性
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