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粪肠球菌中青霉素酶基因的转移

Mobilization of the penicillinase gene in Enterococcus faecalis.

作者信息

Chow J W, Perri M B, Thal L A, Zervos M J

机构信息

Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201.

出版信息

Antimicrob Agents Chemother. 1993 May;37(5):1187-9. doi: 10.1128/AAC.37.5.1187.

DOI:10.1128/AAC.37.5.1187
PMID:8517713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187930/
Abstract

Enterococcus faecalis SF4855 is a beta-lactamase-producing isolate resistant to high levels of gentamicin, with determinants for these resistances on the chromosome. SF4855 transferred both determinants into E. faecalis FA2-2 and UV202 at a frequency of 10(-9) in the presence of the MLS plasmid pYN120. beta-Lactamase and gentamicin resistance probes hybridized to three locations on the chromosome of FA2-2 transconjugants on contour-clamped homogeneous electric field electrophoresis. The study results suggest mobilization of the beta-lactamase determinant.

摘要

粪肠球菌SF4855是一株产β-内酰胺酶的菌株，对高水平庆大霉素耐药，其耐药决定簇位于染色体上。在存在MLS质粒pYN120的情况下，SF4855以10^(-9)的频率将这两个耐药决定簇转移至粪肠球菌FA2-2和UV202中。β-内酰胺酶和庆大霉素耐药探针在轮廓夹钳均匀电场电泳中与FA2-2转接合子染色体上的三个位置杂交。研究结果提示β-内酰胺酶决定簇发生了转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ac/187930/3273aec00abd/aac00027-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ac/187930/3273aec00abd/aac00027-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04ac/187930/3273aec00abd/aac00027-0290-a.jpg

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本文引用的文献

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Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance.耐药质粒从表皮葡萄球菌向金黄色葡萄球菌的转移：耐药性接合交换的证据。
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Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance.粪肠球菌菌株中三种质粒脱氧核糖核酸分子的特性：鉴定一种决定红霉素抗性的质粒
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Serious infection due to beta-lactamase-producing Streptococcus faecalis with high-level resistance to gentamicin.由产β-内酰胺酶且对庆大霉素高度耐药的粪肠球菌引起的严重感染。
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Antimicrob Agents Chemother. 1988 Jan;32(1):122-4. doi: 10.1128/AAC.32.1.122.