Richter W
Department of Experimental Orthopaedics, Orthopaedic University Hospital, Heidelberg, Germany.
J Intern Med. 2009 Oct;266(4):390-405. doi: 10.1111/j.1365-2796.2009.02153.x.
Cartilage repair is a very successful pioneering area of regenerative medicine in which techniques of in situ regeneration and cell and tissue transplantation dominate over cell-free approaches to generate durable neocartilage. This review concentrates on advantages and limitations of mesenchymal stem cell (MSC)-based cartilage repair strategies induced by marrow stimulation. Detailed knowledge on the biology of MSC will be discussed in light of the requirements for MSC recruitment, retention, proliferation and chondrogenic differentiation. An improved microenvironment with timely correlated signals from biomaterials, growth factors, proteases, adjacent cartilage and subchondral bone may be key to a third generation of techniques to regenerate hyaline cartilage.
软骨修复是再生医学中一个非常成功的前沿领域，其中原位再生技术以及细胞和组织移植技术比无细胞方法更具优势，能够生成持久的新软骨。本综述聚焦于骨髓刺激诱导的基于间充质干细胞（MSC）的软骨修复策略的优势与局限性。将根据MSC募集、留存、增殖和成软骨分化的要求，讨论关于MSC生物学的详细知识。具有来自生物材料、生长因子、蛋白酶、相邻软骨和软骨下骨的及时相关信号的改良微环境，可能是第三代透明软骨再生技术的关键。
