Laboratory of Reproductive Behaviour, Veterinary Medical School, Autonomous University of Tlaxcala, P.C. 90000, Tlaxcala, Mexico.
J Ethnopharmacol. 2009 Dec 10;126(3):506-11. doi: 10.1016/j.jep.2009.09.006. Epub 2009 Sep 16.
To analyse the pro-ejaculatory properties of the proverbial Mexican plant oquichpatli, Senecio cardiophyllus, in an animal model for the study of ejaculation in spinal and anaesthetised male rats.
The aqueous crude extract of Senecio cardiophyllus (at 0.4, 1.2 and 4 mg/kg) was i.v. administered to (a) anaesthetised and spinalised male rats after spinal cord transection and (b) anaesthetised and spinalised male rats previous to the inhibition of ejaculation elicited by repeated urethral stimulation. The motor pattern of ejaculation and the development of its inhibition were analysed under the influence of the aqueous crude extract of Senecio cardiophyllus and compared to urethrally induced ejaculations.
Systemic administration of the Senecio cardiophyllus aqueous crude extract, at all tested doses, induced the ejaculatory response in male rats. This response was featured by a statistically significant augmented number of ejaculatory discharges when compared to control animals. Oquichpatli-induced ejaculatory responses included the expression of autonomic and motor components of ejaculation and the potent expulsion of urethral contents and seminal plugs. Administration of oquichpatli aqueous crude extract prevented the inhibition of ejaculation elicited by urethral stimulation by promoting a statistically significant increase in the expression of ejaculatory motor patterns.
Present findings show by the first time that the aqueous crude extract of Senecio cardiophyllus possesses the ability to increase the ejaculatory capacity in male rats.
分析著名的墨西哥植物奥基奇帕特里（Senecio cardiophyllus）在脊髓和麻醉雄性大鼠射精研究中的动物模型中的促射精特性。
Senecio cardiophyllus 的水提粗提取物（0.4、1.2 和 4 mg/kg）静脉注射给药至（a）脊髓横断后的麻醉和脊髓化雄性大鼠，和（b）麻醉和脊髓化雄性大鼠，以抑制由重复尿道刺激引起的射精。在 Senecio cardiophyllus 水提粗提取物的影响下分析射精的运动模式及其抑制的发展，并与尿道诱导的射精进行比较。
Senecio cardiophyllus 的水提粗提取物在所有测试剂量下的全身给药均可诱导雄性大鼠的射精反应。与对照动物相比，这种反应的特征是射精排放次数明显增加。奥基奇帕特里诱导的射精反应包括自主和运动成分的表达以及尿道内容物和精液栓的有力排出。奥基奇帕特里水提粗提取物的给药通过促进射精运动模式表达的统计学显著增加，防止了尿道刺激引起的射精抑制。
目前的研究结果首次表明，Senecio cardiophyllus 的水提粗提取物具有增加雄性大鼠射精能力的能力。
