Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA.
J Psychiatr Res. 2010 Feb;44(3):177-82. doi: 10.1016/j.jpsychires.2009.08.001. Epub 2009 Sep 19.
Reduced concentrations of docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6) have been reported in the postmortem bipolar disorder (BD) brain. Additionally, an increased prevalence of BD has been related to low dietary intake of fish, and dietary supplements containing fish products or DHA have been reported to ameliorate BD symptoms. These observations suggest that brain lipid metabolism, particularly involving DHA, is disturbed in BD. To test this suggestion, concentrations of different lipids were measured using internal standards in postmortem frontal cortex from eight BD patients and six matched controls. Compared with control cortex, the BD cortex showed no statistically significant difference in mean concentrations (per gram wet weight) of "stable" lipids (total lipid, total phospholipid, individual phospholipids, or cholesterol), of unesterified fatty acids, or of esterified DHA or AA within stable lipids. Fractional esterified AA and DHA concentrations also did not differ significantly between groups. Some fatty acid concentration differences were found in low-abundant cholesteryl ester. These results do not support the hypothesis of disturbed brain lipid concentrations, including concentrations of AA and DHA, in BD. Positron emission tomography might be used, however, to see if brain AA or DHA kinetics are disturbed in the disease.
二十二碳六烯酸（DHA，22:6n-3）和花生四烯酸（AA，20:4n-6）的浓度降低已在死后双相情感障碍（BD）大脑中报道。此外，BD 的患病率增加与鱼类饮食摄入量低有关，并且据报道，含有鱼类产品或 DHA 的饮食补充剂可以改善 BD 症状。这些观察结果表明，BD 中大脑脂质代谢，特别是 DHA 参与的代谢，受到干扰。为了验证这一假设，使用内标物测量了死后额皮质中不同脂质的浓度，该皮质来自 8 名 BD 患者和 6 名匹配对照。与对照皮质相比，BD 皮质的“稳定”脂质（总脂质、总磷脂、个体磷脂或胆固醇）、未酯化脂肪酸或稳定脂质内的酯化 DHA 或 AA 的平均浓度（每克湿重）没有统计学上的显著差异。酯化 AA 和 DHA 的分数浓度在组间也没有显著差异。在低丰度的胆甾醇酯中发现了一些脂肪酸浓度差异。这些结果不支持 BD 中大脑脂质浓度（包括 AA 和 DHA 浓度）受到干扰的假说。然而，正电子发射断层扫描可能用于观察疾病中大脑 AA 或 DHA 动力学是否受到干扰。
