嗅沟深度：精神分裂症早期胚胎发育紊乱的一个标志物？
Depth of the olfactory sulcus: a marker of early embryonic disruption in schizophrenia?
作者信息
Turetsky Bruce I, Crutchley Patrick, Walker Jeffrey, Gur Raquel E, Moberg Paul J
机构信息
Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA.
出版信息
Schizophr Res. 2009 Nov;115(1):8-11. doi: 10.1016/j.schres.2009.09.005. Epub 2009 Sep 20.
Abstract
Embryonic insults during early gestation increase the risk of schizophrenia. Abnormal forebrain development during this period is often characterized by a shallow olfactory sulcus. The adjacent orbital sulcus does not develop until the third trimester and so is immune to early intrauterine insults. We measured olfactory and orbital sulcal depths in 36 patients and 28 control subjects. Patients had shallower olfactory sulci, but normal orbital sulci. Olfactory and orbital sulcal depths were correlated in controls, but not in patients. Olfactory sulcal depth may therefore be a biomarker denoting an early embryonic disruption in individuals at risk for schizophrenia.
摘要
妊娠早期的胚胎损伤会增加患精神分裂症的风险。在此期间前脑发育异常通常表现为嗅沟变浅。相邻的眶沟直到妊娠晚期才发育，因此不受早期宫内损伤的影响。我们测量了36例患者和28名对照者的嗅沟和眶沟深度。患者的嗅沟较浅，但眶沟正常。嗅沟和眶沟深度在对照组中呈正相关，但在患者中无相关性。因此，嗅沟深度可能是一种生物标志物，表明有精神分裂症风险的个体存在早期胚胎发育障碍。
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