Nordon Ian M, Hinchliffe Robert J, Holt Peter J, Loftus Ian M, Thompson Matthew M
St George's Vascular Institute, St James' Wing, St George's Hospital, London, UK.
Vascular. 2009 Sep-Oct;17(5):253-63. doi: 10.2310/6670.2009.00046.
Atherosclerotic plaques are a feature of abdominal aortic aneurysms (AAAs). Atherosclerosis and AAA appear to share similar risk factors. These observations have led to the conclusion that AAAs are a consequence of advanced atherosclerosis.This review explores current theories regarding the pathogenesis of AAA and their implications for treatment.A systematic literature search was conducted using the search terms abdominal aortic aneurysm, atherosclerosis, pathogenesis, and systemic disease. Articles were categorized according to the association of AAAs with atherosclerosis, arteriomegaly, peripheral aneurysm, systemic expression, genetics, autoimmunity, oxidative stress, and systemic disease. Twenty-nine articles reporting changes in the systemic vasculature associated with AAA and 12 articles examining the shared risk factor hypothesis were identified.There is insufficient evidence to confirm that AAAs are the result of advanced atherosclerosis. The bulk of evidence points to AAA disease being a systemic disease of the vasculature, with a predetermined genetic susceptibility leading to a phenotype governed by environmental factors.
动脉粥样硬化斑块是腹主动脉瘤（AAA）的一个特征。动脉粥样硬化和腹主动脉瘤似乎有相似的危险因素。这些观察结果得出结论，腹主动脉瘤是晚期动脉粥样硬化的结果。本综述探讨了当前关于腹主动脉瘤发病机制的理论及其对治疗的影响。使用搜索词腹主动脉瘤、动脉粥样硬化、发病机制和全身性疾病进行了系统的文献检索。文章根据腹主动脉瘤与动脉粥样硬化、动脉扩张、周围动脉瘤、全身表达、遗传学、自身免疫、氧化应激和全身性疾病的关联进行分类。确定了29篇报告与腹主动脉瘤相关的全身血管系统变化的文章和12篇研究共同危险因素假说的文章。没有足够的证据证实腹主动脉瘤是晚期动脉粥样硬化的结果。大量证据表明，腹主动脉瘤疾病是一种血管系统的全身性疾病，具有预先确定的遗传易感性，导致由环境因素决定的表型。
