Chen Theodore, Adamson Peter A
Department of Head and Neck Surgery, Southern California Permanente Medical Group, Los Angeles, California, USA.
J Otolaryngol Head Neck Surg. 2009 Oct;38(5):580-6.
To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively.
Prospective, double-blind, randomized trial.
Accredited outpatient surgery centre.
Study subjects received scheduled doses of either oral ibuprofen 400 mg or acetaminophen/codeine 600/60 mg four times a day through postoperative day 3. They recorded their pain level on a 10 cm visual analogue scale, as well as any untoward side effects, at scheduled times throughout the first 3 postoperative days. Severity of bruising was assessed on postoperative day 4. Any postoperative hematomas were managed and recorded.
There was no significant difference in pain relief or average bruising scores between the two groups. Subjects receiving ibuprofen had significantly fewer adverse side effects and were less likely to change medications than those receiving acetaminophen with codeine. None of the patients in either group developed a postoperative hematoma.
Ibuprofen 400 mg is as effective as acetaminophen/codeine 600/60 mg for pain relief following cosmetic facial surgery. Ibuprofen is better tolerated, with fewer side effects, than acetaminophen with codeine. Ibuprofen given postoperatively does not result in increased bruising or increased incidence of hematoma.
比较布洛芬与对乙酰氨基酚加可待因在面部整形手术后用于术后镇痛的疗效和副作用，并评估术后服用布洛芬是否会导致更严重的瘀伤或更高的血肿发生率。
前瞻性、双盲、随机试验。
经认可的门诊手术中心。
研究对象在术后第3天前每天按计划服用400毫克口服布洛芬或600/60毫克对乙酰氨基酚/可待因，每日4次。他们在术后前3天的规定时间，使用10厘米视觉模拟量表记录疼痛程度以及任何不良反应。在术后第4天评估瘀伤的严重程度。对任何术后血肿进行处理并记录。
两组之间在疼痛缓解或平均瘀伤评分方面没有显著差异。与服用对乙酰氨基酚加可待因的受试者相比，服用布洛芬的受试者出现的不良反应明显更少，且更换药物的可能性更小。两组患者均未出现术后血肿。
400毫克布洛芬在面部整形手术后的镇痛效果与600/60毫克对乙酰氨基酚/可待因相当。布洛芬的耐受性更好，副作用比与对乙酰氨基酚加可待因更少。术后服用布洛芬不会导致瘀伤加重或血肿发生率增加。
