从秀丽紫金牛中分离得到的两种新型三萜皂苷对人神经胶质瘤 U251MG 细胞具有细胞毒性。

Two new triterpenoid saponins cytotoxic to human glioblastoma U251MG cells from Ardisia pusilla.

机构信息

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, P. R. China.

出版信息

Chem Biodivers. 2009 Sep;6(9):1443-52. doi: 10.1002/cbdv.200800233.

DOI:10.1002/cbdv.200800233

PMID:19774606

Abstract

Two new triterpenoid saponins, ardipusillosides IV and V (1 and 2, resp.), together with one known saponin, ardisiacrispin B(3), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 contains a glycosylated glycerol residue which is a very rare structural feature among triterpenoid glycosides and has been so far found only in the genus Ardisia. All the saponins exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.

摘要

从紫金牛科紫金牛属植物小紫金牛全株中分离得到两个新的三萜皂苷化合物，分别命名为 ardipusilloside IV（1）和 ardipusilloside V（2），以及一个已知化合物 ardisiacrispin B（3）。通过波谱分析和化学转化等方法确定了它们的结构。化合物 1 含有一个糖基化甘油基，这是三萜皂苷中非常罕见的结构特征，迄今仅在紫金牛属中发现。所有的皂苷对人神经胶质瘤 U251MG 细胞均具有显著的细胞毒性，但对原代培养的人星形胶质细胞的生长没有影响。