2008 年台湾肠病毒 71 型的再现：1998 至 2008 年基因与抗原演化的动态。
Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008.
机构信息
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, One University Road, Tainan, 701, Taiwan.
出版信息
J Clin Microbiol. 2009 Nov;47(11):3653-62. doi: 10.1128/JCM.00630-09. Epub 2009 Sep 23.
Abstract
In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. The reemergence in Taiwan of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past 11 years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using neutralization tests revealed that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes. Moreover, analyses of full-length genomic sequences of EV71 circulating in Taiwan during this period showed the occurrence of intra- and interserotypic recombination. Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.
摘要
近年来，肠道病毒 71 型（EV71）已成为亚太地区引发大量手足口病爆发，并伴有严重神经并发症的病原体。2008 年，台湾肠病毒 71 型 B5 基因型的再度出现，导致台湾过去 11 年来爆发最大规模的肠病毒 71 型疫情。系统进化分析表明，1986 年至 2008 年间，B 型至 C 型或 C 型至 B 型的主要基因型变化至少发生了 3 次。此外，通过中和试验进行的 EV71 抗原图谱分析表明，新出现的 EV71 B5 基因型株形成了一个单独的聚类，与 B4 和 C 基因型在抗原上明显不同。此外，对这一时期在台湾流行的 EV71 全长基因组序列分析表明，存在着同种型和异型内重组。因此，建议对 EV71 进行持续监测，包括遗传进化和抗原变化的监测，这可能有助于开发 EV71 疫苗。
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