Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.
作者信息
Chen Alex M, Zhang Min, Wei Dongguang, Stueber Dirk, Taratula Oleh, Minko Tamara, He Huixin
机构信息
Department of Chemistry Rutgers, The State of New Jersey, Newark, NJ 07102, USA.
出版信息
Small. 2009 Dec;5(23):2673-7. doi: 10.1002/smll.200900621.
Abstract
摘要
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Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.通过与可释放的八聚精氨酸转运体偶联克服小分子治疗药物的多药耐药性。
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Mesoporous silica nanoparticles deliver DNA and chemicals into plants.介孔二氧化硅纳米颗粒将DNA和化学物质输送到植物中。
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Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch.通过T(2)磁弛豫开关的磁共振成像确定纳米颗粒载体的解包情况。
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Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs.介孔二氧化硅纳米颗粒作为疏水性抗癌药物的递送系统。
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In vivo imaging of siRNA delivery and silencing in tumors.肿瘤中siRNA递送与沉默的体内成像
Nat Med. 2007 Mar;13(3):372-7. doi: 10.1038/nm1486. Epub 2007 Feb 25.
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siRNA delivery into human T cells and primary cells with carbon-nanotube transporters.利用碳纳米管转运体将小干扰RNA递送至人T细胞和原代细胞。
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