Schulte Daniela, Vogel Martin, Langhans Bettina, Krämer Benjamin, Körner Christian, Nischalke Hans Dieter, Steinberg Verena, Michalk Monika, Berg Thomas, Rockstroh Jürgen K, Sauerbruch Tilman, Spengler Ulrich, Nattermann Jacob
Department of Internal Medicine I, University of Bonn, Bonn, Germany.
J Infect Dis. 2009 Nov 1;200(9):1397-401. doi: 10.1086/605889.
Recently, we showed chronic hepatitis C to be associated with increased expression of HLA-E and identified peptide hepatitis C virus (HCV) core amino acids 35-44 as a ligand for HLA-E that stabilizes HLA-E expression, favoring inhibition of natural killer cell cytotoxicity. Here we describe HLA-E-restricted recognition of peptide HCV core amino acids 35-44 by CD8(+) T cells. Frequency of HLA-E-restricted responses was significantly higher in patients homozygous for the HLA-E(R) allele (60% vs 38%; P = .038). Moreover, we found that the HLA-E(R) allelic variant confers protection against chronic infection with HCV genotypes 2 and 3. Taken together, our data indicate an important immunomodulating function of HLA-E in hepatitis C.
最近，我们发现慢性丙型肝炎与HLA-E表达增加有关，并确定丙型肝炎病毒（HCV）核心氨基酸35 - 44肽段是HLA-E的配体，可稳定HLA-E表达，有利于抑制自然杀伤细胞的细胞毒性。在此，我们描述了CD8(+) T细胞对HCV核心氨基酸35 - 44肽段的HLA-E限制性识别。HLA-E(R)等位基因纯合的患者中，HLA-E限制性反应的频率显著更高（60%对38%；P = 0.038）。此外，我们发现HLA-E(R)等位基因变体可预防HCV 2型和3型的慢性感染。综上所述，我们的数据表明HLA-E在丙型肝炎中具有重要的免疫调节功能。
