Department of Oral and Maxillofacial Plastic Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
J Oral Pathol Med. 2010 Apr;39(4):313-7. doi: 10.1111/j.1600-0714.2009.00829.x. Epub 2009 Sep 17.
This study investigates the prognostic impact of the expression of hypoxia-inducible factor 1alpha (Hif1alpha) and carbonic anhydrase IX (CAIX) detected by immunohistochemistry in oral squamous cell carcinoma (OSCC).
Statistical analysis of immunohistochemical results with clinical parameters including survival outcomes was performed for 80 OSCC patients.
Patients with a low expression of both proteins survived on average 54.8 months, whereas those with an increased expression of Hif1alpha in their tumors combined with a low expression of CAIX survived on average only 37.6 months (P = 0.026). In multivariate Cox's regression hazard analysis, again patients with a low expression of Hif1alpha/CAIX had the best prognosis, whereas patients with increased Hif1alpha and low CAIX expression carried a 4.97-fold increased risk of tumor-related death (P = 0.042).
A co-detection of low Hif1alpha/CAIX expression is significantly correlated with a better prognosis for OSCC patients, which may have implications for therapy options for these patients.
本研究通过免疫组织化学检测口腔鳞状细胞癌（OSCC）中缺氧诱导因子 1α（Hif1α）和碳酸酐酶 IX（CAIX）的表达，探讨其预后意义。
对 80 例 OSCC 患者的免疫组织化学结果与临床参数（包括生存结局）进行统计学分析。
两种蛋白低表达的患者平均存活 54.8 个月，而肿瘤中 Hif1α高表达且 CAIX 低表达的患者平均仅存活 37.6 个月（P = 0.026）。在多变量 Cox 回归危险分析中，再次发现 Hif1α/CAIX 低表达的患者预后最佳，而 Hif1α 升高和 CAIX 低表达的患者肿瘤相关死亡风险增加 4.97 倍（P = 0.042）。
Hif1α/CAIX 低表达的共同检测与 OSCC 患者的预后显著相关，这可能对这些患者的治疗选择具有重要意义。
