Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Br J Nutr. 2010 Jan;103(2):149-52. doi: 10.1017/S0007114509991681. Epub 2009 Sep 28.
Habitual coffee consumption is associated with the prevention of type 2 diabetes, which often accompanies diabetic nephropathy. However, the relationship between coffee consumption and kidney function is unclear. Therefore, we investigated the associations between habitual coffee consumption and kidney function and damage assessed by the estimated glomerular filtration rate (eGFR) and proteinuria using dipstick urinalysis, respectively, in a cross-sectional study of 342 apparently healthy adults. Habitual coffee consumption was defined as drinking one or more cups of coffee per d. eGFR in coffee consumers (n 182; 80.1 (sd 15.0) ml/min per 1.73 m(2)) was significantly higher than that in non-coffee consumers (n 160; 76.9 (sd 12.6) ml/min per 1.73 m(2)) (P < 0.05). Multivariate logistic analysis showed that, compared with non-coffee consumption, coffee consumption was significantly associated with normal or increased eGFR (NIGFR) ( >or= 90 ml/min per 1.73 m(2)), but not proteinuria, which was not attenuated, even after adjustment for age, sex, smoking, tea consumption and other cardiovascular risks (OR 2.91; 95 % CI 1.51, 5.61; P = 0.001). When we took into account eGFR measured 1 year before in a subgroup of the subjects (n 262), coffee consumption (n 142) had a significant relationship with eGFR, which was consistently higher with a difference of 4.0 ml/min per 1.73 m(2) compared with non-coffee consumption (P = 0.01; two-way repeated ANOVA). Similar associations were observed in both sexes when data were reanalysed according to sex. In conclusion, our findings suggest that habitual coffee consumption is associated with NIGFR independently of clinical confounders. Further studies are needed to confirm this association and to explore whether the effect of coffee consumption on eGFR is beneficial for the kidney.
习惯性喝咖啡与 2 型糖尿病的预防有关，而 2 型糖尿病常伴有糖尿病肾病。然而，喝咖啡与肾功能之间的关系尚不清楚。因此，我们在一项横断面研究中调查了习惯性喝咖啡与肾功能和蛋白尿分别用估计肾小球滤过率（eGFR）和尿试纸分析评估的肾脏损伤之间的关系，该研究纳入了 342 名看似健康的成年人。习惯性喝咖啡定义为每天喝一杯或多杯咖啡。喝咖啡者（n=182）的 eGFR（80.1（sd=15.0）ml/min/1.73m2）明显高于不喝咖啡者（n=160）（76.9（sd=12.6）ml/min/1.73m2）（P<0.05）。多变量 logistic 分析显示，与不喝咖啡相比，喝咖啡与正常或增加的 eGFR（NIGFR）（≥90ml/min/1.73m2）显著相关，但与蛋白尿无关，即使在调整年龄、性别、吸烟、喝茶和其他心血管风险因素后，相关性仍未减弱（OR=2.91；95%CI 1.51，5.61；P=0.001）。在考虑了研究对象中（n=262）的亚组中 eGFR 1 年前测量的结果后，咖啡的摄入（n=142）与 eGFR 有显著关系，与不喝咖啡相比，eGFR 始终高出 4.0ml/min/1.73m2（P=0.01；双向重复方差分析）。根据性别重新分析数据时，在两性中均观察到类似的关联。总之，我们的研究结果表明，习惯性喝咖啡与 NIGFR 独立于临床混杂因素相关。需要进一步的研究来证实这种关联，并探讨喝咖啡对 eGFR 的影响是否对肾脏有益。
