Department of Neuroscience, S Giovanni di Dio Hospital, 88900 Crotone, Italy.
J Neurol Sci. 2009 Dec 15;287(1-2):60-3. doi: 10.1016/j.jns.2009.09.008. Epub 2009 Sep 26.
Restless legs syndrome (RLS) is a sensorimotor disorder characterised by a distressing urge to move the legs. Several clinical conditions have been associated with RLS, such as iron deficiency, uraemia, pregnancy, polyneuropathy and Diabetes Mellitus (DM). However the causes remain unknown in about 70-80% of cases.
To evaluate the role of glucose metabolism abnormalities in idiopathic RLS.
We enrolled 132 consecutive patients with idiopathic RLS associated with normal fasting glycaemia and 128 control subjects. We evaluated glucose and insulin levels after a 2-h oral glucose tolerance test (2h-OGTT) in patients and control subjects. In addition we determined Insulin Resistance (IR) by Homa-Index.
After 2h-OGTT, the prevalence of glucose metabolism abnormalities was significantly higher in patients with RLS than in controls (P=.002). Impaired Glucose Tolerance (IGT) was found in 54 (41%) patients and in 23 (18%) controls, while a new-diagnosed DM (NDDM) was found in 25 (19%) patients and in 8 (6%) controls. The IR showed no significant differences between patients and controls.
Our study suggests that IGT (prediabetes) is frequently associated with idiopathic RLS. We propose to perform a 2h-OGTT in idiopathic RLS patients with normal fasting glycaemia.
不宁腿综合征（RLS）是一种以腿部不适为特征的感觉运动障碍，其腿部有强烈的移动冲动。有几种临床情况与 RLS 相关，如缺铁、尿毒症、妊娠、多发性神经病和糖尿病（DM）。然而，约 70-80%的病例其病因仍不清楚。
评估葡萄糖代谢异常在特发性 RLS 中的作用。
我们纳入了 132 例连续的特发性 RLS 患者，这些患者与正常空腹血糖相关，且纳入了 128 例对照。我们评估了患者和对照组在 2 小时口服葡萄糖耐量试验（2h-OGTT）后血糖和胰岛素水平。此外，我们通过 Homa-Index 确定胰岛素抵抗（IR）。
在 2h-OGTT 后，RLS 患者的葡萄糖代谢异常患病率明显高于对照组（P=.002）。54 例（41%）患者出现葡萄糖耐量受损（IGT），23 例（18%）对照组出现 IGT，而 25 例（19%）患者出现新诊断的 DM（NDDM），8 例（6%）对照组出现 NDDM。IR 在患者和对照组之间无显著差异。
我们的研究表明，IGT（糖尿病前期）常与特发性 RLS 相关。我们建议对空腹血糖正常的特发性 RLS 患者进行 2h-OGTT。
