唾液腺对辐射的敏感性：从动物模型到治疗方法
Sensitivity of salivary glands to radiation: from animal models to therapies.
作者信息
Grundmann O, Mitchell G C, Limesand K H
机构信息
Department of Nutritional Sciences, University of Arizona, 1177 E 4th St., Shantz 421,PO Box 210038, Tucson, AZ 85721, USA.
出版信息
J Dent Res. 2009 Oct;88(10):894-903. doi: 10.1177/0022034509343143.
Abstract
Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.
摘要
头颈部癌的放射治疗会在正常唾液腺中引发显著的继发性副作用，导致这些患者的生活质量下降。唾液腺对辐射极为敏感，并且会对放射治疗表现出急性和慢性反应。本综述将讨论正常唾液腺放射敏感性的临床意义，比较用于研究辐射诱导唾液腺损伤的动物模型，阐述治疗进展，并展望该领域的未来发展方向。
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