School of Biology and Environmental Science, University College Dublin, BioSciences Institute, University College Cork, Ireland.
Nucleic Acids Res. 2010 Jan;38(Database issue):D69-74. doi: 10.1093/nar/gkp788. Epub 2009 Sep 25.
'Recoding' is a term used to describe non-standard read-out of the genetic code, and encompasses such phenomena as programmed ribosomal frameshifting, stop codon readthrough, selenocysteine insertion and translational bypassing. Although only a small proportion of genes utilize recoding in protein synthesis, accurate annotation of 'recoded' genes lags far behind annotation of 'standard' genes. In order to address this issue, provide a service to researchers in the field, and offer training data for developers of gene-annotation software, we have gathered together known cases of recoding within the Recode database. Recode-2 is an improved and updated version of the database. It provides access to detailed information on genes known to utilize translational recoding and allows complex search queries, browsing of recoding data and enhanced visualization of annotated sequence elements. At present, the Recode-2 database stores information on approximately 1500 genes that are known to utilize recoding in their expression--a factor of approximately three increase over the previous version of the database. Recode-2 is available at http://recode.ucc.ie.
“重编码”是一个用于描述非标准遗传密码读码的术语，包括核糖体移码、终止密码通读、硒代半胱氨酸插入和翻译旁路等现象。虽然只有一小部分基因在蛋白质合成中利用重编码，但“重编码”基因的准确注释远远落后于“标准”基因的注释。为了解决这个问题，为该领域的研究人员提供服务，并为基因注释软件的开发人员提供培训数据，我们在 Recode 数据库中收集了已知的重编码案例。Recode-2 是该数据库的改进和更新版本。它提供了对已知利用翻译重编码的基因的详细信息，并允许进行复杂的搜索查询、重编码数据的浏览和注释序列元素的增强可视化。目前，Recode-2 数据库存储了约 1500 个已知在其表达中利用重编码的基因的信息，这一数字相对于上一个版本的数据库增加了约三倍。Recode-2 可在 http://recode.ucc.ie 上获取。
