Al-Hussaini Reema, Mahasneh Adel M
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman 11942, Jordan.
Molecules. 2009 Sep 3;14(9):3425-35. doi: 10.3390/molecules14093425.
Antimicrobial and antiquorum sensing (AQS) activities of fourteen ethanolic extracts of different parts of eight plants were screened against four Gram-positive, five Gram-negative bacteria and four fungi. Depending on the plant part extract used and the test microorganism, variable activities were recorded at 3 mg per disc. Among the Grampositive bacteria tested, for example, activities of Laurus nobilis bark extract ranged between a 9.5 mm inhibition zone against Bacillus subtilis up to a 25 mm one against methicillin resistant Staphylococcus aureus. Staphylococcus aureus and Aspergillus fumigatus were the most susceptible among bacteria and fungi tested towards other plant parts. Of interest is the tangible antifungal activity of a Tecoma capensis flower extract, which is reported for the first time. However, minimum inhibitory concentrations (MIC's) for both bacteria and fungi were relatively high (0.5-3.0 mg). As for antiquorum sensing activity against Chromobacterium violaceum, superior activity (>17 mm QS inhibition) was associated with Sonchus oleraceus and Laurus nobilis extracts and weak to good activity (8-17 mm) was recorded for other plants. In conclusion, results indicate the potential of these plant extracts in treating microbial infections through cell growth inhibition or quorum sensing antagonism, which is reported for the first time, thus validating their medicinal use.
对8种植物不同部位的14种乙醇提取物针对4种革兰氏阳性菌、5种革兰氏阴性菌和4种真菌进行了抗菌和抗群体感应（AQS）活性筛选。根据所使用的植物部位提取物和测试微生物的不同，每片含3毫克提取物时记录到了不同的活性。例如，在所测试的革兰氏阳性菌中，月桂树皮提取物的活性范围为对枯草芽孢杆菌的抑菌圈直径9.5毫米至对耐甲氧西林金黄色葡萄球菌的抑菌圈直径25毫米。金黄色葡萄球菌和烟曲霉在所测试的细菌和真菌中对其他植物部位最为敏感。值得关注的是首次报道的南非凌霄花提取物具有明显的抗真菌活性。然而，对细菌和真菌的最低抑菌浓度（MIC）相对较高（0.5 - 3.0毫克）。至于对紫色杆菌的群体感应抑制活性，苦苣菜和月桂提取物具有较强活性（群体感应抑制>17毫米），其他植物的活性则为弱到中等（8 - 17毫米）。总之，结果表明这些植物提取物通过抑制细胞生长或群体感应拮抗作用来治疗微生物感染的潜力，这是首次报道，从而验证了它们的药用价值。
