Abu-Odeh Ala', Fino Leen, Al-Absi Ghadeer, Alnatour Dalal, Al-Darraji Mohanad, Shehadeh Mayadah, Suaifan Ghadeer
Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman, Jordan.
Department of Clinical Chemistry and Therapeutics, Applied Science Private University, Amman, Jordan.
Heliyon. 2023 Jun 7;9(6):e17081. doi: 10.1016/j.heliyon.2023.e17081. eCollection 2023 Jun.
Jordan is rich in the flora of ethnobotanical importance. This scoping review aims to highlight the ethnopharmacological value of Jordanian medicinal plants using the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A total of one hundred twenty-four articles published between 2000 and 2022 obtained from PubMed, EBSCO, and Google Scholar databases were included in this review. These plants own several classes of secondary bioactive metabolites, including alkaloids, flavonoids, phenolics, and terpenes. Jordanian plants exhibited potential therapeutic activity against various tumors, bacterial infections, elevated blood glucose levels, hyperlipidemia, platelets aggregation disorders, and gastrointestinal disorders. Phytochemicals' biological activities depend on their structures, parts used, methods of extraction, and evaluation model. In conclusion, this review highlights the need of researching Jordan's abundant naturally occurring medicinal plants and their phytochemicals as novel lead molecules in drug discovery and development. Studying active phytochemicals for disease treatment will help develop drugs for safe treatment and cure in the future.
约旦拥有丰富的具有民族植物学重要性的植物群。本综述旨在利用系统评价和Meta分析的首选报告项目（PRISMA）指南，突出约旦药用植物的民族药理学价值。本综述纳入了2000年至2022年间从PubMed、EBSCO和谷歌学术数据库中获取的共124篇文章。这些植物含有几类次生生物活性代谢物，包括生物碱、黄酮类、酚类和萜类。约旦的植物对各种肿瘤、细菌感染、血糖水平升高、高脂血症、血小板聚集紊乱和胃肠道疾病表现出潜在的治疗活性。植物化学物质的生物活性取决于它们的结构、使用部位、提取方法和评估模型。总之，本综述强调了研究约旦丰富的天然药用植物及其植物化学物质作为药物发现和开发中新型先导分子的必要性。研究用于疾病治疗的活性植物化学物质将有助于未来开发出安全治疗和治愈疾病的药物。
