一种从见血封喉乳汁中提取的新型细胞毒性19-降强心甾内酯。
A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria.
作者信息
Dai Hao-Fu, Gan Yu-Juan, Que Dong-Mei, Wu Jiao, Wen Zhen-Chang, Mei Wen-Li
机构信息
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
Molecules. 2009 Sep 21;14(9):3694-9. doi: 10.3390/molecules14093694.
A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
从见血封喉（Antiaris toxicaria (Pers.) Lesch，桑科）的乳汁中分离出一种新的去甲强心苷，命名为见血封喉苷H（1）。基于高分辨快原子轰击质谱（HRFAB-MS）和光谱技术（红外光谱、紫外光谱、一维和二维核磁共振）对其结构进行了鉴定。采用MTT法检测发现，化合物1在体外对K562、SGC-7901、SMMC-7721和HeLa细胞系具有显著的细胞毒性。
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