Goldstein L B
Department of Medicine (Neurology), Duke University Medical Center, Durham, N.C.
Stroke. 1990 Nov;21(11 Suppl):III139-42.
Laboratory research during the past decade has begun to provide insights into the neurobiologic basis of functional recovery after brain injury. It is clear that drugs influencing specific neurotransmitters also can influence the recovery process. Some of these drugs may be beneficial, but others may be detrimental. Some of the difficulties in interpreting the results of these behavioral studies are reviewed, and potential mechanisms of drug effects are discussed. These types of studies are leading to an increased awareness of the potentially harmful effects of some drugs often given to stroke patients. Pharmacotherapy designed to enhance functional recovery after stroke may be possible in the future.
在过去十年间，实验室研究已开始为脑损伤后功能恢复的神经生物学基础提供见解。显然，影响特定神经递质的药物也会影响恢复过程。其中一些药物可能有益，但其他药物可能有害。本文回顾了这些行为学研究结果解读中的一些困难，并讨论了药物作用的潜在机制。这类研究正使人们越来越意识到一些常用于中风患者的药物可能存在有害影响。未来有可能设计出旨在增强中风后功能恢复的药物疗法。
