Hassid E I
Department of Neurology, Madigan Army Medical Center, Fort Lewis, WA 98431-5000, USA.
Mil Med. 1995 May;160(5):223-6.
The concept of pharmacological intervention for recovery from brain injury is by no means new. However, most rehabilitation physicians still do not incorporate it into their practice. Over the past several years, scientific evidence has begun to reveal that certain medications can limit the extent of cerebral damage and others have the capacity to influence neurological recovery. Rehabilitation medicine emerged in the military out of a desperate need to rehabilitate injured soldiers as quickly and efficiently as possible. Although casualties are much less common in today's post-Cold War military, the need for expeditious neurorehabilitation still remains because of the growing military retired population. In keeping with this view, this paper begins by reviewing the neurobiological basis of spontaneous recovery after cerebral injury. It continues with a discussion about the pharmacological basis of motor recovery after stroke, and concludes by presenting some clinical guidelines useful in helping to expedite as well as maximize neurological recovery.
通过药物干预促进脑损伤恢复的概念绝非新鲜事物。然而，大多数康复医师仍未将其纳入临床实践。在过去几年中，科学证据已开始表明，某些药物可限制脑损伤的程度，而其他一些药物则具有影响神经恢复的能力。康复医学起源于军队，是出于尽快高效地使受伤士兵康复的迫切需求。尽管在当今冷战后的军队中伤亡情况已不那么常见，但由于退伍军人数量不断增加，对快速神经康复的需求依然存在。基于这一观点，本文首先回顾脑损伤后自发恢复的神经生物学基础。接着讨论中风后运动恢复的药理学基础，最后提出一些有助于加速并最大化神经恢复的临床指南。
