National Metal and Materials Technology Center, National Science and Technology Development Agency, Ministry of Science and Technology, 114 Paholyothin Road, Klong 1, Pathumthani, 12120, Klongluang, Thailand.
J Mater Sci Mater Med. 2010 Feb;21(2):419-29. doi: 10.1007/s10856-009-3883-1. Epub 2009 Sep 26.
The conversion of newly developed three dimensionally printed calcium sulfate hemihydrate (70-90% wt/wt CaSO(4).0.5.H(2)O) based materials to calcium phosphate bioceramics by phosphorization in di-sodium hydrogen phosphate solution at 80 degrees C for 4, 8, 16 and 24 h was studied. It was found that transformation rate, phase composition and mechanical properties were influenced by porosity in the fabricated samples and by the duration of the phosphorization treatment. Formulation with 85% CaSO(4).0.5 H(2)O showed the fastest transformation rate and resulted in the highest flexural modulus and strength. Depending on the materials formulation, XRD, FT-IR and EDS revealed that calcium deficient hydroxyapatite (CDHA) or a mixture of CDHA and dicalcium phosphate anhydrous (DCPA) were the resulting phases in the transformed samples. After cell culturing for 14 and 21 days, human osteoblast cells were observed to attach to and attain normal morphology on the surface of the transformed sample containing 85% CaSO(4).0.5 H(2)O. Various sizes and shapes of mineralized nodules were also found after 21 days.
研究了在 80°C 的磷酸氢二钠溶液中，通过磷化作用将新开发的三维打印硫酸钙半水合物（70-90wt%wt/wt CaSO（4）。0.5.H（2）O）基材料转化为磷酸钙生物陶瓷，磷化时间分别为 4、8、16 和 24 h。结果表明，转化率、相组成和力学性能受制备样品的孔隙率和磷化处理时间的影响。85% CaSO（4）。0.5 H（2）O 配方显示出最快的转化速率，并且得到的抗弯强度和强度最高。根据材料配方，XRD、FT-IR 和 EDS 表明，转化样品中生成的是缺钙羟磷灰石（CDHA）或 CDHA 和二水磷酸二钙（DCPA）的混合物。细胞培养 14 和 21 天后，观察到在含有 85% CaSO（4）的转化样品表面，人成骨细胞能够附着并获得正常形态。0.5 H（2）O。在第 21 天还发现了各种大小和形状的矿化结节。
