Gbureck Uwe, Hölzel Tanja, Biermann Isabell, Barralet Jake E, Grover Liam M
Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070 Wurzburg, Germany.
J Mater Sci Mater Med. 2008 Apr;19(4):1559-63. doi: 10.1007/s10856-008-3373-x. Epub 2008 Jan 31.
Custom made tricalcium phosphate/calcium pyrophosphate bone substitutes with a well-defined architecture were fabricated in this study using 3D powder printing with tricalcium phosphate (TCP) powder and a liquid phase of phosphoric acid. The primary formed matrix of dicalcium phosphate dihydrate (DCPD, brushite) was converted in a second step to calcium pyrophosphate (CPP) by heat treatment in the temperature range 1,100-1,300 degrees C. The structures exhibited compressive strengths between 0.8 MPa and 4 MPa after sintering at 1,100-1,250 degrees C, higher strengths were obtained by increasing the amount of pyrophosphate formed in the matrix due to a post-hardening regime prior sintering as well as by the formation of a glass phase from TCP and calcium pyrophosphate above 1,280 degrees C, which resulted in a strong densification of the samples and compressive strength of >40 MPa.
在本研究中，使用磷酸三钙（TCP）粉末和磷酸液相通过3D粉末打印制造了具有明确结构的定制磷酸三钙/焦磷酸钙骨替代物。初始形成的二水磷酸二钙（DCPD，透钙磷石）基质在第二步中通过在1100-1300摄氏度的温度范围内进行热处理转化为焦磷酸钙（CPP）。在1100-1250摄氏度烧结后，这些结构的抗压强度在0.8MPa至4MPa之间，通过在烧结前的后硬化过程中增加基质中形成的焦磷酸钙量，以及在12,80摄氏度以上由TCP和焦磷酸钙形成玻璃相，导致样品强烈致密化且抗压强度>40MPa，从而获得了更高的强度。
