Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy.
Trans R Soc Trop Med Hyg. 2010 Jan;104(1):29-32. doi: 10.1016/j.trstmh.2009.08.001. Epub 2009 Sep 27.
Cystic echinococcosis (CE) is a zoonotic helminthic disease, which is widely distributed throughout the world. Although G1 is the Echinococcus granulosus genotype most commonly involved in CE in humans, the prevalence of infection with other genotypes, such as G6, may be higher than previously thought. We performed molecular analysis to identify which E. granulosus genotypes are the causative agents of CE in humans in Kenya's Turkana district. During a Hydatid Control Programme in 1993-1994, 71 cyst fluid isolates of E. granulosus were collected during PAIR (puncture, aspiration, injection, re-aspiration) sessions. DNA was amplified for two genes from 59 isolates. Of these, 49 isolates (83%) were identified as G1 and 10 (17%) as G6. This is the highest prevalence of G6 detected in humans of the Old World, and our results suggest that, in highly contaminated environments, G6 might be of greater public health significance than previously believed.
泡型包虫病（CE）是一种人畜共患的寄生虫病，广泛分布于世界各地。尽管 G1 是与人类 CE 最相关的细粒棘球蚴基因型，但感染其他基因型（如 G6）的流行率可能高于先前的认知。我们进行了分子分析，以确定肯尼亚图尔卡纳地区引起人类 CE 的棘球蚴基因型。在 1993-1994 年的包虫病控制计划期间，在 PAIR（穿刺、抽吸、注射、再抽吸）过程中收集了 71 个棘球蚴囊液分离株。从 59 个分离株中扩增了两个基因的 DNA。其中，49 个分离株（83%）鉴定为 G1，10 个分离株（17%）鉴定为 G6。这是在旧世界人类中检测到的 G6 最高流行率，我们的结果表明，在高度污染的环境中，G6 可能比之前认为的具有更大的公共卫生意义。
