ICBMS, UMR 5246, Univ Lyon 1, Villeurbanne, F69622, France.
Chem Commun (Camb). 2011 Jul 14;47(26):7303-19. doi: 10.1039/c1cc11541c. Epub 2011 May 9.
This review treats the biological properties of the various anionic calix[n]arenes, both as soluble forms and in the colloidal state. The complexation of these molecules with amino-acids, peptides and proteins is discussed, as is their interaction with model membranes. The complexations with various Active Pharmaceutical Ingredients as complexes, for tamoxifen as solid state and colloidal structures, are treated in depth. Two sections deal with the direct biological action of the calix[n]arenes and their use as biosensors. A final section deals with the toxicity, in reality the lack of toxicity of the calix[n]arenes.
这篇综述探讨了各种阴离子杯[环]芳烃的生物特性，包括其可溶性形式和胶体状态。讨论了这些分子与氨基酸、肽和蛋白质的络合，以及它们与模型膜的相互作用。还深入探讨了与各种活性药物成分作为配合物的络合，包括作为固态和胶体结构的他莫昔芬。有两个部分涉及杯[环]芳烃的直接生物作用及其作为生物传感器的应用。最后一部分讨论了杯[环]芳烃的毒性，实际上它们缺乏毒性。
