在单个可编程位点上用 7-脱氮-脱氧腺苷特异性修饰质粒 DNA 的功能后果。
Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Chem Commun (Camb). 2009 Oct 21(39):5820-2. doi: 10.1039/b914843d. Epub 2009 Sep 8.
Abstract
Replacement of a single dA nucleotide positioned at a programmed site in a DNA plasmid with its 7-deaza-analog is described together with its complete resistance to restriction enzymatic cleavage.
摘要
描述了在 DNA 质粒的一个预定位置用其 7-脱氮类似物替代单个 dA 核苷酸的情况，以及其对限制酶切割的完全抗性。
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